Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The influence of glycosaminoglycans and crosslinking agents on the phenotype of hepatocytes cultured on collagen gels.

Human & experimental toxicology - 1 Feb 2003

Kataropoulou Margarita, Henderson Catherine, Grant Helen

Abstract excerpt

The use of primary hepatocyte cultures as in vitro models for studying xenobiotic metabolism and toxicity is limited by the loss of liver-specific differentiated functions with time in culture and the inability of the cells to proliferate. The aim of this study was to investigate the effect of incorporating 20% chondroitin-6-sulphate (Ch6SO4), a glycosaminoglycan (GAG), into collagen gels (0.3% w/v) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Chondroitin Sulfates

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Collagen

Share to Cross-Linking Reagents

Share to Diamines

Share to Drug Combinations

Share to Hepatocytes

Source

Identifiers

PMID: 12693829
DOI: 10.1191/0960327103ht320oa

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The influence of glycosaminoglycans and crosslinking agents on the phenotype of hepatocytes cultured on collagen gels.PMID 12693829Read ↗

Manipulation of the phenotype of immortalised rat hepatocytes by different culture configurations and by dimethyl sulphoxide.Semantic proximity Read ↗

Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes.Semantic proximity Read ↗

Stable lentiviral-mediated expression of Cytochrome P450 2D6 in HepaRG cells: New means for <i>in vitro</i> assessment of xenobiotic biotransformation and cytotoxicitySemantic proximity Read ↗

Complex Interplay between Serum and Fibroblasts in 3D Hepatocyte Co-cultureSemantic proximity Read ↗

Hepatocellular phenotype in vitro is influenced by biophysical features of the collagenous substratum.Semantic proximity Read ↗

Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture.Semantic proximity Read ↗

Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytesSemantic proximity Read ↗

Differentiated properties of hepatocytes induced from pancreatic cells.Semantic proximity Read ↗

Influence of the isolation method on the stability of differentiated phenotype in cultured rat hepatocytes.Semantic proximity Read ↗

Long-term primary cultures of adult human hepatocytes.Semantic proximity Read ↗

Activation of rat hepatic stellate cells leads to loss of glutathione S-transferases and their enzymatic activity against products of oxidative stress.Semantic proximity Read ↗

Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.