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Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes

1 Jan 2000

Abstract excerpt

The aim of this study was to test suitable culture conditions for maintaining normal cellular cytoarchitecture and inducibility of P450 enzymes in primary cultures of human hepatocytes by prototypical inducers. The selectivity and sensitivity of a sandwich culture system were determined by treating cultures with a number of clinically relevant drugs that are known to be inducers of either rodent and/or human P450...

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PMID: 10789495
DOI: 10.1002/(sici)1099-0461(2000)14:4<177::aid-jbt1>3.0.co;2-4

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