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Article

Hepatocellular phenotype in vitro is influenced by biophysical features of the collagenous substratum.

Hepatology (Baltimore, Md.) - 1 Feb 1991

Lindblad W J, Schuetz E G, Redford K S, Guzelian P S

Abstract excerpt

Hepatocytes maintained on different substrata in vitro possess strikingly different morphological and biochemical features. Rounded, multicellular aggregates of hepatocytes are seen if the cells are plated onto Matrigel, a reconstituted basement membrane, whereas a flattened, monolayer of hepatocytes is observed with Vitrogen. Hepatocellular protein synthesis is much greater on the Matrigel, although collagen...

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PMID: 1995439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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