Article

Complex Interplay between Serum and Fibroblasts in 3D Hepatocyte Co-culture

2018-03-22

Abstract excerpt

Previous studies have suggested that primary hepatocytes cultured in vitro undergo a rapid loss of function. On the other hand, in the clinic, drug induced liver injury typically manifests 5 days to 3 months after starting a medication. Thus, novel approaches that can maintain the function of primary human hepatocytes for longer durations of time may enable the development of improved in vitro assays for detecti...

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Literature Corpus work: ee16ab6f-eb59-5bcc-9b13-d748042267c3
DOI: 10.1101/286088

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