Article
Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes.
Mutation research - 20 Apr 2003
Martelli Antonietta, Mattioli Francesca, Angiola Marianna, Reimann Roland, Brambilla Giovanni
Abstract excerpt
Sex steroids, due to the generally negative responses observed in routinely employed standard genotoxicity assays, are considered epigenetic carcinogens. Some doubts on this conviction are raised by the results of recent studies providing evidence that cyproterone acetate and two structural analogues, chlormadinone acetate and megestrol acetate, are genotoxic in female rats but only for the liver, and in primary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.