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Stable lentiviral-mediated expression of Cytochrome P450 2D6 in HepaRG cells: New means for <i>in vitro</i> assessment of xenobiotic biotransformation and cytotoxicity

2025-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Primary cultures of Human Hepatocytes (PHH) are the gold standard to investigate drug-hepatotoxicity in vitro , however, large-scale studies using these primary liver cells are not possible because of the shortage in liver biopsies. HepaRG model is often considered as the closest surrogate to PHH for toxicity studies in vitro . However, differentiated HepaRG cells express very low levels of th...

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Literature Corpus work
b85ef4a2-7b89-521c-b1b1-75bed5541cd4
DOI
10.1101/2025.01.25.634872
Open publication

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Stable lentiviral-mediated expression of Cytochrome P450 2D6 in HepaRG cells: New means for <i>in vitro</i> assessment of xenobiotic biotransformation and cytotoxicityDOI 10.1101/2025.01.25.634872
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