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Article

Single-chain polymorphism analysis in long QT syndrome using planar waveguide fluorescent biosensors.

Analytical biochemistry - 15 Apr 2003

Tolley Samuel E, Wang Hsu-kun, Smith Richard S, Christensen Douglas A, Herron James N

Abstract excerpt

Rapid detection of single nucleotide polymorphisms (SNPs) has potential applications in both genetic screening and pharmacogenomics. Planar waveguide fluorescent biosensor technology was employed to detect SNPs using a simple hybridization assay with the complementary strand ("capture oligo") immobilized on the waveguide. This technology allows real-time measurements of DNA hybridization kinetics. Under normal...

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PMID: 12689832
DOI: 10.1016/s0003-2697(03)00008-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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