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Article

Detection of single nucleotide polymorphism using tension-dependent stochastic behavior of a single-molecule template.

Journal of the American Chemical Society - 6 Jul 2011

Koirala Deepak, Yu Zhongbo, Dhakal Soma, Mao Hanbin

Abstract excerpt

Single nucleotide polymorphism (SNP) is the most common genetic variation among individuals. The association of SNP with individual's response to pathogens, phenotypic variations, and gene functions emphasizes the importance of sensitive and reliable SNP detection for biomedical diagnosis and therapy. To increase sensitivity, most approaches employ amplification steps, such as PCR, to generate detectable signals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21639132
DOI: 10.1021/ja201976r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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