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Article

Accurate zygote-specific discrimination of single-nucleotide polymorphisms using microfluidic electrochemical DNA melting curves.

Angewandte Chemie (International ed. in English) - 17 Mar 2014

Yang Allen H J, Hsieh Kuangwen, Patterson Adriana S, Ferguson B Scott, Eisenstein Michael, Plaxco Kevin W, Soh H Tom

Abstract excerpt

We report the first electrochemical system for the detection of single-nucleotide polymorphisms (SNPs) that can accurately discriminate homozygous and heterozygous genotypes using microfluidics technology. To achieve this, our system performs real-time melting-curve analysis of surface-immobilized hybridization probes. As an example, we used our sensor to analyze two SNPs in the apolipoprotein E (ApoE) gene,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24520069
DOI: 10.1002/anie.201310059
PMCID: PMC3992926

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