Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single nucleotide polymorphism genotyping using short, fluorescently labeled locked nucleic acid (LNA) probes and fluorescence polarization detection.

Nucleic acids research - 1 Sept 2002

Simeonov Anton, Nikiforov Theo T

Abstract excerpt

Locked nucleic acids (LNAs) are synthetic nucleic acid analogs that bind to complementary target molecules (DNA, RNA or LNA) with very high affinity. At the same time, this binding affinity is decreased substantially when the hybrids thus formed contain even a single mismatched base pair. We have exploited these properties of LNA probes to develop a new method for single nucleotide polymorphism genotyping. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Composition
Share to Fluorescence Polarization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Dyes

Share to Nucleic Acid Denaturation

Share to Nucleic Acid Hybridization

Share to Oligonucleotide Probes

Share to Rhodamines

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 12202779
DOI: 10.1093/nar/gnf090
PMCID: PMC137436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single nucleotide polymorphism genotyping using short, fluorescently labeled locked nucleic acid (LNA) probes and fluorescence polarization detection.PMID 12202779Read ↗

Single nucleotide polymorphism genotyping using locked nucleic acid (LNA).Semantic proximity Read ↗

Locked nucleic acid (LNA) single nucleotide polymorphism (SNP) genotype analysis and validation using real-time PCR.Semantic proximity Read ↗

Universal SNP genotyping assay with fluorescence polarization detection.Semantic proximity Read ↗

Enhanced allele-specific PCR discrimination in SNP genotyping using 3' locked nucleic acid (LNA) primers.Semantic proximity Read ↗

High-throughput genotyping with primer extension fluorescent polarization detection.Semantic proximity Read ↗

Single-nucleotide polymorphism (SNP) genotyping using cationic conjugated polymers in homogeneous solution.Semantic proximity Read ↗

Emerging technologies for hybridization based single nucleotide polymorphism detection.Semantic proximity Read ↗

Novel (phenylethynyl)pyrene-LNA constructs for fluorescence SNP sensing in polymorphic nucleic acid targets.Semantic proximity Read ↗

Suspension arrays for high throughput, multiplexed single nucleotide polymorphism genotyping.Semantic proximity Read ↗

Fluorescence polarization for single nucleotide polymorphism genotyping.Semantic proximity Read ↗

Unlabeled oligonucleotide probes modified with locked nucleic acids for improved mismatch discrimination in genotyping by melting analysis.Semantic proximity Read ↗

Real-time genotyping with oligonucleotide probes containing locked nucleic acids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.