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Article

DNA-probes for the highly sensitive identification of single nucleotide polymorphism using single-molecule spectroscopy.

FEBS letters - 17 Apr 2007

Friedrich Achim, Hoheisel Jörg D, Marmé Nicole, Knemeyer Jens-Peter

Abstract excerpt

This article presents a new, highly sensitive method for the identification of single nucleotide polymorphisms (SNPs) in homogeneous solutions using fluorescently labeled hairpin-structured oligonucleotides (smart probes) and fluorescence single-molecule spectroscopy. While the hairpin probe is closed, fluorescence intensity is quenched due to close contact between the chromophore and several guanosine residues....

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Base Sequence
DNA Probes
Nucleic Acid Hybridization
Polymorphism, Single Nucleotide
Sequence Analysis, DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spectrometry, Fluorescence

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PMID: 17399707
DOI: 10.1016/j.febslet.2007.03.031

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