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Article

Allelotypes as potential prognostic markers in ovarian carcinoma treated with cisplatin-based chemotherapy.

International journal of molecular medicine - 1 May 2003

Nakayama Satoru, Nakayama Kentaro, Takebayashi Yuji, Hata Kohkichi, Fujiwaki Ritsuto, Fukumoto Manabu, Miyazaki Kohji

Abstract excerpt

We analyzed a series of ovarian carcinomas from patients treated with cisplatin-based chemotherapy for loss of heterozygosity (LOH) to determine the relationship between microsatellite alteration and prognosis. Patients with tumors that had lost alleles at loci 3p14-21, 12qter, or 17p13.3 showed significantly reduced survival compared to patients with tumors that retained both alleles at those loci. The 5-year...

Topics

Alleles
Antineoplastic Agents
Biomarkers, Tumor
Carcinoma
Cisplatin
Female
Humans
Loss of Heterozygosity
Microsatellite Repeats
Ovarian Neoplasms
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Survival Rate

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PMID: 12684700

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