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Article

Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 2 Mar 2018

Nordquist Sarah K, Smith Sofia R, Pierce Jonathan T

Abstract excerpt

Individuals with Down syndrome have neurological and muscle impairments due to an additional copy of the human 21st chromosome (HSA21). Only a few of ∼200 HSA21 genes encoding proteins have been linked to specific Down syndrome phenotypes, while the remainder are understudied. To identify poorly characterized HSA21 genes required for nervous system function, we studied behavioral phenotypes caused by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29367452
DOI: 10.1534/g3.118.200019
PMCID: PMC5844316

Genes

PDXK
SYNJ1
CBS
DONSON
NCAM2
POFUT2
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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