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Article

Characterization of Caenorhabditis elegans Homologs of the Down Syndrome Candidate Gene DYRK1A

1 Feb 2003

Abstract excerpt

The pathology of trisomy 21/Down syndrome includes cognitive and memory deficits. Increased expression of the dual-specificity protein kinase DYRK1A kinase (DYRK1A) appears to play a significant role in the neuropathology of Down syndrome. To shed light on the cellular role of DYRK1A and related genes we identified three DYRK/minibrain-like genes in the genome sequence of Caenorhabditis elegans, termed mbk-1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12618396
DOI: 10.1093/genetics/163.2.571

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Characterization of Caenorhabditis elegans Homologs of the Down Syndrome Candidate Gene DYRK1APMID 12618396Read ↗

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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeSemantic proximity Read ↗

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