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Article

Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006

Ramanathan Sheela, Gagnon Julien, Leblanc Chantal, Rottapel Robert, Ilangumaran Subburaj

Abstract excerpt

SOCS1(-/-) mice accumulate within the thymus and periphery CD8(+) lymphocytes that express memory cell markers and display heightened in vitro responses to common gamma-chain cytokines. To investigate whether dysregulated homeostasis of T lymphocytes and acquisition of memory phenotype by CD8(+) cells in SOCS1(-/-) mice were mediated by IL-7 and/or IL-15 in vivo, we have generated SOCS1(-/-)IL-7(-/-),...

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Source

Identifiers

PMID: 16547238
DOI: 10.4049/jimmunol.176.7.4029

Genes

SOCS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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