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Article

Reduction of p53 dosage renders mice hypersensitive to 7, 12-dimethylbenz(alpha) anthracene-induced salivary gland tumorigenesis.

Anticancer research - 1 Jan 2000

Ide Fumio, Kitada Munenori, Sakashita Hideaki, Kusama Kaoru

Abstract excerpt

BACKGROUND: The role of p53 during the evolutionary steps of experimental salivary gland tumorigenesis has not been fully elucidated. MATERIALS AND METHODS: Each genotype group of p53-deficient mice received a single intrasubmandibular gland injection of 1 mg of 7, 12-dimethylbenz(a)anthracene. In addition to the routine histopathological examination, immunohistochemical detection of p53 protein and molecular...

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Identifiers

PMID: 12680213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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