Article
Response of the spleen of Balb/c and p53-transgenic mice to low doses of carcinogen and to polyclonal antibodies generated against the soluble 53 kDa protein.
Anticancer research - 1 Jan 2000
Tendler Y, Ben-Hur H, Gurevich P, Sandler B, Berman V, Zinder O, Zusman I
Abstract excerpt
BACKGROUND: We have previously reported that p53-transgenic mice are highly sensitive to low doses of a carcinogen and to vaccination with soluble 53 kDa antibodies, compared to normal mice. The splenic manifestation of this strain dependent hypersensitivity was investigated immunohistochemically and morphometrically. METHODS: The spleen was obtained from Balb/c and human p53 promoter-CAT transgenic mice. Mice...
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