Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice.

doi:10.1002/mc.2940090309

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Article

Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice.

Molecular carcinogenesis - 1 Mar 1994

Jerry D J, Butel J S, Donehower L A, Paulson E J, Cochran C, Wiseman R W, Medina D

Abstract excerpt

We conducted experiments to determine if p53 alterations, which are frequent in human breast cancers, were also common in murine mammary tumors. In 13 mammary tumors from 7,12-dimethylbenz[a]anthracene (DMBA)-treated BALB/c mice were immunohistochemically analyzed for overexpression of p53; p53 p...

Topics

9,10-Dimethyl-1,2-benzanthracene
Alleles
Animals
Genes, p53
Mammary Neoplasms, Experimental
Mice
Mice, Inbred BALB C
Mice, Knockout
Mutagenesis
Precancerous Conditions

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