Article
Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters.
Disease markers - 1 Jan 2018
Yahouédéhou Sètondji Cocou Modeste Alexandre, Carvalho Magda Oliveira Seixas, Oliveira Rodrigo Mota, Santiago Rayra Pereira, da Guarda Caroline Conceição, Carvalho Suellen Pinheiro, Ferreira Júnia Raquel Dutra, Aleluia Milena Magalhães, Adorno Elisângela Vitória, Gonçalves Marilda de Souza
Abstract excerpt
This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters in sickle cell anemia patients under hydroxyurea (SCA-HU+). We evaluated hematologic and biochemical parameters by electronic methods and SNPs by PCR-RFLP and multiplex PCR in 35 SCA-HU+ patients and 67 SCA-HU- patients. The HbS, total cholesterol, lactate dehydrogenase, aspartate...
Topics
- Adolescent
- Adult
- Anemia, Sickle Cell
- Antisickling Agents
- Biomarkers
- Child
- Child, Preschool
- Cytochrome P-450 CYP2E1
- Female