Article
Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.
Experimental and molecular pathology - 1 Dec 2008
Segditsas Stefania, Sieber Oliver M, Rowan Andrew, Setien Fernando, Neale Kay, Phillips Robin K S, Ward Robyn, Esteller Manel, Tomlinson Ian P M
Abstract excerpt
Germline mutations in the tumour suppressor APC cause familial adenomatous polyposis (FAP), and somatic mutations are common in sporadic colorectal cancers (CRCs). Hypermethylation of APC promoter 1A has been reported in a substantial proportion of sporadic CRCs and may cause transcriptional silencing. Methylation has been proposed as an alternative to mutation or loss of heterozygosity as a mechanism of gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.