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Article

Cu(I)-dependent biogenesis of the galactose oxidase redox cofactor.

The Journal of biological chemistry - 13 Jun 2003

Whittaker Mei M, Whittaker James W

Abstract excerpt

Galactose oxidase is a copper metalloenzyme containing a novel protein-derived redox cofactor in its active site, formed by cross-linking two residues, Cys228 and Tyr272. Previous studies have shown that formation of the tyrosyl-cysteine (Tyr-Cys) cofactor is a self-processing step requiring only copper and dioxygen. We have investigated the biogenesis of cofactor-containing galactose oxidase from pregalactose...

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PMID: 12672814
DOI: 10.1074/jbc.M300112200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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