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Article

The role of distal tryptophan in the bifunctional activity of catalase-peroxidases.

Biochemical Society transactions - 1 May 2001

Regelsberger G, Jakopitsch C, Furtmüller P G, Rueker F, Switala J, Loewen P C, Obinger C

Abstract excerpt

Catalase-peroxidases are bifunctional peroxidases exhibiting an overwhelming catalase activity and a substantial peroxidase activity. Here we present a kinetic study of the formation and reduction of the key intermediate compound I by probing the role of the conserved tryptophan at the distal haem cavity site. Two wild-type proteins and three mutants of Synechocystis catalase-peroxidase (W122A and W122F) and...

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Identifiers

PMID: 11356135
DOI: 10.1042/0300-5127:0290099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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