Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Active-site maturation and activity of the copper-radical oxidase GlxA are governed by a tryptophan residue.

The Biochemical journal - 20 Feb 2017

Chaplin Amanda K, Svistunenko Dimitri A, Hough Michael A, Wilson Michael T, Vijgenboom Erik, Worrall Jonathan A R

Abstract excerpt

GlxA from Streptomyces lividans is a mononuclear copper-radical oxidase and a member of the auxiliary activity family 5 (AA5). Its domain organisation and low sequence homology make it a distinct member of the AA5 family in which the fungal galactose 6-oxidase (Gox) is the best characterised. GlxA is a key cuproenzyme in the copper-dependent morphological development of S. lividans with a function that is linked...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cations, Divalent
Share to Copper

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusarium

Share to Oxidoreductases

Share to Protein Domains

Share to Structural Homology, Protein

Share to Tryptophan

Share to Tyrosine

Source

Identifiers

PMID: 28093470
DOI: 10.1042/BCJ20160968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Active-site maturation and activity of the copper-radical oxidase GlxA are governed by a tryptophan residue.PMID 28093470Read ↗

The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces.Semantic proximity Read ↗

Morphological development and cytochrome c oxidase activity in Streptomyces lividans are dependent on the action of a copper bound Sco protein.Semantic proximity Read ↗

Cu(I)-dependent biogenesis of the galactose oxidase redox cofactor.Semantic proximity Read ↗

Heterogeneity in the Histidine-brace Copper Coordination Sphere in Auxiliary Activity Family 10 (AA10) Lytic Polysaccharide Monooxygenases.Semantic proximity Read ↗

Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.Semantic proximity Read ↗

Mutational dissection of a hole hopping route in a lytic polysaccharide monooxygenase (LPMO).Semantic proximity Read ↗

The stacking tryptophan of galactose oxidase: a second-coordination sphere residue that has profound effects on tyrosyl radical behavior and enzyme catalysis.Semantic proximity Read ↗

Role of a strictly conserved active site tyrosine in cofactor genesis in the copper amine oxidase from Hansenula polymorpha.Semantic proximity Read ↗

Crystal structures of the Met148Leu and Ser86Asp mutants of rusticyanin from Thiobacillus ferrooxidans: insights into the structural relationship with the cupredoxins and the multi copper proteins.Semantic proximity Read ↗

Understanding the roles of strictly conserved tryptophan residues in O2 producing chlorite dismutases.Semantic proximity Read ↗

Yeast cytochrome c oxidase: a model system to study mitochondrial forms of the haem-copper oxidase superfamily.Semantic proximity Read ↗

Crystal structures of pristine and oxidatively processed lignin peroxidase expressed in Escherichia coli and of the W171F variant that eliminates the redox active tryptophan 171. Implications for the reaction mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.