Article
Redox robustness drives LPMO evolution.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jan 2026
Ayuso-Fernández Iván, Emrich-Mills Tom Z, Golten Ole, Forsberg Zarah, Hall Kelsi R, Nagy László G, Sørlie Morten, Kjendseth Røhr Åsmund, Eijsink Vincent G H
Abstract excerpt
Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are exceptionally powerful small redox enzymes that master the controlled generation and productive use of potentially damaging hydroxyl radicals in what is essentially a H2O2-driven peroxygenase reaction. We have used ancestral sequence reconstruction and enzyme resurrection to unravel evolutionary steps leading to this exceptional catalytic ability....
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