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Article

Does the interaction between maternal folate intake and the methylenetetrahydrofolate reductase polymorphisms affect the risk of cleft lip with or without cleft palate?

American journal of epidemiology - 1 Apr 2003

van Rooij Iris A L M, Vermeij-Keers Christl, Kluijtmans Leo A J, Ocké Marga C, Zielhuis Gerhard A, Goorhuis-Brouwer Sieneke M, van der Biezen Jan-Jaap, Kuijpers-Jagtman Anne-Marie, Steegers-Theunissen Régine P M

Abstract excerpt

Periconceptional folic acid supplementation may reduce the risk of cleft lip with or without cleft palate (CL(P)). Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene reduce availability of 5-methyltetrahydrofolate, the predominant circulating form of folate. To determine the effect of MTHFR C677T and MTHFR A1298C genotypes and haplotypes on CL(P) risk and the interaction with maternal...

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Source

Identifiers

PMID: 12672677
DOI: 10.1093/aje/kwg005

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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