Article
Family-based association study of the MTHFR polymorphism C677T in patients with nonsyndromic cleft lip and palate from central Europe.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 May 2008
Reutter Heiko, Birnbaum Stefanie, Lacava Amalia Diaz, Mende Meinhard, Henschke Henning, Bergé Stefaan, Braumann Bert, Lauster Carola, Schiefke Franziska, Wenghoefer Matthias, Saffar Mitra, Reich Rudolf, Scheer Martin, Kramer Franz-Josef, Knapp Michael, Mangold Elisabeth
Abstract excerpt
OBJECTIVE: The 677C-->T allele in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been implicated in the etiology of nonsyndromic cleft lip and palate (CL/P). This study involved a family-based association study of the MTHFR polymorphism. PATIENTS/PARTICIPANTS: We examined 181 patients with CL/P of central European descent and their parents for this variant. RESULTS: The transmission disequilibrium...
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