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Article

5,10-Methylenetetrahydrofolate reductase single nucleotide polymorphisms and gene-environment interaction analysis in non-syndromic cleft lip/palate.

European journal of oral sciences - 1 Apr 2014

Estandia-Ortega Bernardette, Velázquez-Aragón José A, Alcántara-Ortigoza Miguel A, Reyna-Fabian Miriam E, Villagómez-Martínez Sandra, González-Del Angel Ariadna

Abstract excerpt

Non-syndromic cleft lip/palate (NSCL/P) is a common congenital defect in Mexico. Periconceptional intake of folic acid (FA) may reduce the risk of this malformation. Although the 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme participates in folate metabolism, several studies failed to find any association between NSCL/P and the MTHFR C677T and A1298C polymorphisms. However, interactions among NSCL/P,...

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Source

Identifiers

PMID: 24460828
DOI: 10.1111/eos.12114

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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