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Article

Maternal C677T MTHFR polymorphism and environmental factors are associated with cleft lip and palate in a Mexican population.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Aug 2013

Ibarra-Lopez Jose Jesus, Duarte Patricia, Antonio-Vejar Veronica, Calderon-Aranda Emma S, Huerta-Beristain Gerardo, Flores-Alfaro Eugenia, Moreno-Godinez Ma Elena

Abstract excerpt

INTRODUCTION: Nonsyndromic cleft lip and cleft palate (CL/P) is associated with environmental, nutritional, and genetic factors. Maternal polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene have been associated with CL/P. OBJECTIVES: To determine the relationship between the risk of having a child with CL/P and maternal C677T and A1298C MTHFR polymorphisms, the intake of folate supplements, and...

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Source

Identifiers

PMID: 23787444
DOI: 10.2310/JIM.0b013e31829a7e7e

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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