The human tyrosine hydroxylase gene promoter.

doi:10.1016/s0169-328x(02)00694-0

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Article

The human tyrosine hydroxylase gene promoter.

Brain research. Molecular brain research - 10 Apr 2003

Kessler Mark A, Yang Ming, Gollomp Kandace L, Jin Hao, Iacovitti Lorraine

Abstract excerpt

13.329 kilobases of the single copy human tyrosine hydroxylase (hTH) gene were isolated from a genomic library. The 5' flanking 11 kilobases fused to the reporter green fluorescent protein (GFP) drove high level expression in TH+ cells of the substantia nigra of embryonic and adult transgenic mice as determined by double label fluorescence microscopy. To provide a basis for future analysis of polymorphisms and...

Topics

Animals
Basal Ganglia
Brain Diseases
Cell Differentiation
Dopamine
Female
Fetus
Gene Expression Regulation, Enzymologic
Green Fluorescent Proteins
Humans
Luminescent Proteins
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation
Neurons
Promoter Regions, Genetic
Rats

Source

Open in PubMed

Identifiers

PMID: 12670698
DOI: 10.1016/s0169-328x(02)00694-0

Genes

HOXA4
HOXA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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