DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype.

doi:10.1016/0169-328x(94)90121-x

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Article

DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype.

Brain research. Molecular brain research - 1 Jul 1994

Banerjee S A, Roffler-Tarlov S, Szabo M, Frohman L, Chikaraishi D M

Abstract excerpt

Transgenic mice bearing 4.8 kilobases (kb) of upstream rat tyrosine hydroxylase (TH) sequences linked to a human growth hormone gene (hGH) exhibited cell-specific expression of hGH in all the appropriate catecholaminergic neurons in the central nervous system (CNS), although with different penetr...

Topics

Aging
Animals
Brain
Catecholamines
Dwarfism
Female
Gene Expression
Growth Hormone
Humans
Immunohistochemistry
Male
Mice
Mice, Transgenic
Neurons
Organ Specificity
Phenotype
Promoter Regions, Genetic
Rats

Source

Open in PubMed

Identifiers

PMID: 7968381
DOI: 10.1016/0169-328x(94)90121-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7968381-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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