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Article

Characterization of the human TARDBP gene promoter.

Scientific reports - 17 May 2021

Baralle Marco, Romano Maurizio

Abstract excerpt

The expression of TDP-43, the main component of neuronal intracellular inclusions across a broad spectrum of ALS and FTD disorders, is developmentally regulated and studies in vivo have shown that TDP-43 overexpression can be toxic, even before observation of pathological aggregates. Starting from these observations, the regulation of its expression at transcriptional level might represent a further key element...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34002018
DOI: 10.1038/s41598-021-89973-z
PMCID: PMC8129075

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