Article
Quantitative effects on gene silencing by allelic variation at a tetranucleotide microsatellite.
Human molecular genetics - 15 Aug 2001
Albanèse V, Biguet N F, Kiefer H, Bayard E, Mallet J, Meloni R
Abstract excerpt
Microsatellites are common repeated sequences, which are useful as genetic markers and lack any clearly established function. In a previous study we suggested that an intronic polymorphic TCAT repeat in the tyrosine hydroxylase (TH) gene, the microsatellite HUMTH01, may regulate transcription. The TH gene encodes the rate-limiting enzyme in the synthesis of catecholamines, and the microsatellite HUMTH01 has been...
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