Article
Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor.
Biochemical and biophysical research communications - 28 Jul 2006
Kim Soo Min, Yang Jae Won, Park Mi Jung, Lee Joon-Kyu, Kim Seung U, Lee Young Seek, Lee Myung Ae
Abstract excerpt
Tyrosine hydroxylase (TH), the biosynthetic enzyme of catecholamine, is synthesized specifically in catecholaminergic neurons. Thus, it is possible that neuronal cell type-specific expression of this gene is coordinately regulated. One of the neuron-specific transcription regulators, neuron-restrictive silencer factor (NRSF)/repressor element 1 (RE1) silencing transcription factor (REST), represses the expression...
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