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Article

V34I and V34A substitutions within the factor XIII activation peptide segment (28-41) affect interactions with the thrombin active site.

Thrombosis and haemostasis - 1 Apr 2003

Trumbo Toni A, Maurer Muriel C

Abstract excerpt

In the blood coagulation cascade, thrombin helps activate Factor XIII by cleaving the Factor XIII Activation Peptide at the R37-G38 peptide bond. The common polymorphism V34L yields a Factor XIII that is more easily activated than the wildtype enzyme. Peptides based on the Factor XIII (28-41) ((28)TVELQGVVPRGVNL(41)) sequence serve as an important model system for evaluating how to regulate thrombin activation of...

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PMID: 12669118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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