Article
Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin.
Biochemistry - 8 May 2018
Peacock Riley B, Davis Jessie R, Markwick Phineus R L, Komives Elizabeth A
Abstract excerpt
Thrombin normally cleaves fibrinogen to promote coagulation; however, binding of thrombomodulin to thrombin switches the specificity of thrombin toward protein C, triggering the anticoagulation pathway. The W215A thrombin mutant was reported to have decreased activity toward fibrinogen without significant loss of activity toward protein C. To understand how mutation of Trp215 may alter thrombin specificity,...
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