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Article

Serine 380 (P14) --> glutamate mutation activates antithrombin as an inhibitor of factor Xa.

The Journal of biological chemistry - 11 Feb 2000

Futamura A, Gettins P G

Abstract excerpt

Heparin regulates the inhibitory activity of antithrombin. It has been proposed that residues P15 and P14 are expelled from beta-sheet A of antithrombin by heparin binding, permitting better interaction of the reactive center loop with factor Xa. We have made a P14 antithrombin variant (S380E) to create an activated inhibitory form of antithrombin in which P14 is already expelled from beta-sheet A. S380E...

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Source

Identifiers

PMID: 10660568
DOI: 10.1074/jbc.275.6.4092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Serine 380 (P14) --> glutamate mutation activates antithrombin as an inhibitor of factor Xa.PMID 10660568Read ↗

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