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Article

Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis.

Hepatology (Baltimore, Md.) - 1 Apr 2003

Huang Yi-Shin, Chern Herng-Der, Su Wei-Juin, Wu Jaw-Ching, Chang Shi-Chuan, Chiang Chi-Huei, Chang Full-Young, Lee Shou-Dong

Abstract excerpt

Most cases with antituberculosis drug-induced hepatitis have been attributed to isoniazid. Isoniazid is metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. However, the role of CYP2E1 in this hepatotoxicity has not yet been reported. The aim of this study was to evaluate whether the polymorphism of the CYP2E1 gene is associated with antituberculosis drug-induced...

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Source

Identifiers

PMID: 12668988
DOI: 10.1053/jhep.2003.50144

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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