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NAT 2 and CYP 2 E 1 polymorphisms associated with antituberculosis drug‐induced hepatotoxicity in C hinese patients

17 Apr 2012

Abstract excerpt

1. The present study investigated the relationship between antituberculosis (anti-TB) drug-induced hepatotoxicity and genetic polymorphisms of two important drug-metabolizing enzymes involved in the metabolism of isoniazid, namely N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1). 2. A polymerase chain reaction direct sequencing approach was used to detect genetic polymorphisms of the NAT2 and CYP2E1...

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Share to Drug-Induced Hepatotoxicity and Protection
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PMID: 22506592
DOI: 10.1111/j.1440-1681.2012.05713.x

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