Article
Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients.
Memorias do Instituto Oswaldo Cruz - 1 Sept 2011
Teixeira Raquel Lima de Figueiredo, Morato Renata Gomes, Cabello Pedro Hernan, Muniz Ligia Mayumi Kitada, Moreira Adriana da Silva Rezende, Kritski Afrânio Lineu, Mello Fernanda Carvalho Queiroz, Suffys Philip Noel, Miranda Antonio Basilio de, Santos Adalberto Rezende
Abstract excerpt
Isoniazid (INH), one of the most important drugs used in antituberculosis (anti-TB) treatment, is also the major drug involved in hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, such as NAT2, CYP2E1, GSTM1 and GSTT1, that code for drug-metabolising enzymes. Our goal was to examine the polymorphisms in these enzymes as susceptibility factors to...
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