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Article

Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Nov 2007

Cho Hyun-Jung, Koh Won-Jung, Ryu Yon-Ju, Ki Chang-Seok, Nam Myung-Hyun, Kim Jong-Won, Lee Soo-Youn

Abstract excerpt

Antituberculosis drug-induced hepatitis attributed to isoniazid (INH) is one of the most prevalent drug-induced liver injuries. INH is metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. The aim of this study was to evaluate whether polymorphisms of the NAT2 and/or CYP2E1 genes were associated with antituberculosis drug-induced hepatotoxicity in Korean patients....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 17950035
DOI: 10.1016/j.tube.2007.05.012

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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