Hoxb13 is required for normal differentiation and secretory function of the ventral prostate.

doi:10.1242/dev.00432

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Article

Hoxb13 is required for normal differentiation and secretory function of the ventral prostate.

Development (Cambridge, England) - 1 May 2003

Economides Kyriakos D, Capecchi Mario R

Abstract excerpt

The murine prostate is a structure that is made up of four distinct lobes; the dorsal and lateral prostates (often grouped together as the dorsolateral prostate), the anterior (coagulating gland) and the ventral prostate. Previous work has implicated Hox genes in the development of these structures, but how each lobe acquires unique identities for specific functions has not been addressed. In this study, the...

Topics

Animals
Biomarkers
Cell Differentiation
Epithelial Cells
Homeodomain Proteins
Humans
Male
Mice
Mutation
Phenotype
Prostate
Prostatic Secretory Proteins
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 12668621
DOI: 10.1242/dev.00432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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