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Article

Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate.

PloS one - 1 Jan 2016

Bolt C Chase, Negi Soumya, Guimarães-Camboa Nuno, Zhang Huimin, Troy Joseph M, Lu Xiaochen, Kispert Andreas, Evans Sylvia M, Stubbs Lisa

Abstract excerpt

The T-box transcription factor TBX18 is essential to mesenchymal cell differentiation in several tissues and Tbx18 loss-of-function results in dramatic organ malformations and perinatal lethality. Here we demonstrate for the first time that Tbx18 is required for the normal development of periductal smooth muscle stromal cells in prostate, particularly in the anterior lobe, with a clear impact on prostate health...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27120339
DOI: 10.1371/journal.pone.0154413
PMCID: PMC4847854

Genes

TBX18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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