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Article

Noggin is required for normal lobe patterning and ductal budding in the mouse prostate.

Developmental biology - 1 Dec 2007

Cook Crist, Vezina Chad M, Allgeier Sarah H, Shaw Aubie, Yu Min, Peterson Richard E, Bushman Wade

Abstract excerpt

Mesenchymal expression of the BMP antagonist NOGGIN during prostate development plays a critical role in pre-natal ventral prostate development and opposes BMP4-mediated inhibition of cell proliferation during postnatal ductal development. Morphologic examination of newborn Noggin-/- male fetuses revealed genitourinary anomalies including cryptorchidism, incomplete separation of the hindgut from the urogenital...

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Source

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Identifiers

PMID: 18028901
DOI: 10.1016/j.ydbio.2007.09.038
PMCID: PMC2233847

Genes

BMP4
BMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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