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Article

Identification of cryptic nuclear localization signals in the prion protein.

Neurobiology of disease - 1 Mar 2003

Gu Yaping, Hinnerwisch Joerg, Fredricks Rebecca, Kalepu Sudheera, Mishra Ravi Shankar, Singh Neena

Abstract excerpt

Abnormal transport of C-terminally truncated prion protein (PrP) to the nucleus has been reported in cell models of familial prion disorders associated with a stop codon mutation at residues 145 or 160 of the PrP. In both cases, PrP is translocated to the nucleus in an energy-dependent fashion, implying the presence of cryptic nuclear localization signal(s) in this region of PrP. In this report, we describe the...

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PMID: 12667468
DOI: 10.1016/s0969-9961(02)00014-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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