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Article

Misfolding leads the way to unraveling signaling pathways in the pathophysiology of prion diseases.

Prion - 1 Nov 2016

Puig Berta, Altmeppen Hermann C, Glatzel Markus

Abstract excerpt

A misfolded version of the prion protein represents an essential component in the pathophysiology of fatal neurodegenerative prion diseases, which affect humans and animals alike. They may be of sporadic origin, acquired through exogenous introduction of infectious misfolded prion protein, or caused by genetic alterations in the prion protein coding gene. We have recently described a novel pathway linking...

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Identifiers

PMID: 27870599
DOI: 10.1080/19336896.2016.1244593
PMCID: PMC5161300

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