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Article

Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice.

Brain structure & function - 1 Apr 2018

Regensburger Martin, Schreglmann Sebastian R, Stoll Svenja, Rockenstein Edward, Loskarn Sandra, Xiang Wei, Masliah Eliezer, Winner Beate

Abstract excerpt

In the adult mammalian hippocampus, new neurons are constantly added to the dentate gyrus. Adult neurogenesis is impaired in several neurodegenerative mouse models including α-synuclein (a-syn) transgenic mice. Among different a-syn species, a-syn oligomers were reported to be the most toxic species for neurons. Here, we studied the impact of wild-type vs. oligomer-prone a-syn on neurogenesis. We compared the...

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PMID: 29124353
DOI: 10.1007/s00429-017-1561-5
PMCID: PMC5869938

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