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Article

Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice.

Journal of chemical neuroanatomy - 1 Nov 2007

O'Neil Jahn N, Mouton Peter R, Tizabi Yousef, Ottinger Mary Ann, Lei De-Liang, Ingram Donald K, Manaye Kebreten F

Abstract excerpt

Alzheimer's disease (AD) is the most common type of dementia afflicting the elderly. In addition to the presence of cortical senile plaques and neurofibrillary tangles, AD is characterized at autopsy by extensive degeneration of brainstem locus coeruleus (LC) neurons that provide noradrenergic in...

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Identifiers

PMID: 17658239
DOI: 10.1016/j.jchemneu.2007.05.008
PMCID: PMC5483173

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17658239-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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