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Article

Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Nov 2009

Biscaro Barbara, Lindvall Olle, Hock Christoph, Ekdahl Christine T, Nitsch Roger M

Abstract excerpt

The hippocampus is heavily affected by progressive neurodegeneration and beta-amyloid pathology in Alzheimer's disease (AD). The hippocampus is also one of the few brain regions that generate new neurons throughout adulthood. Because hippocampal neurogenesis is regulated by both endogenous and environmental factors, we determined whether it benefits from therapeutic reduction of beta-amyloid peptide...

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Source

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Identifiers

PMID: 19906959
DOI: 10.1523/JNEUROSCI.2055-09.2009
PMCID: PMC6665051

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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