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[Construction of recombinant vaccinia virus co-expressing mutant E6 plus E7 proteins and detection of its immunogenicity and antitumor response].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology - 1 Dec 2002

Zhi Huijun, Han Liqun, Ren Jiao, Tian Houwen, Luo Weifeng, Liang Yu, Ruan Li

Abstract excerpt

OBJECTIVE: To generate a candidate HPV16 vaccine for experimental and therapeutical use for cervical cancer. METHODS: The mutants of HPV16 early E6 and E7 genes were inserted into a vaccinia virus expression vector. A strain of recombinant vaccinia virus was constructed through homologous recombination. RESULTS: Showed that the mutant E6 and E7 genes were located at TK gene region of vaccinia virus Tiantan strain...

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PMID: 12665900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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