Article

New mouse model based on adenocarcinoma 4T1 cells expressing HPV16 E6 and E7 applied to assess the efficacy of therapeutic and prophylactic E6/E7-based HPV16 vaccines

2025-05-21

Abstract excerpt

<title>Abstract</title> <p>Background Development of immunotherapies and vaccines to treat HPV16-associated cancer requires reliable/effective small animal models. We developed such a model based on the murine mammary gland adenocarcinoma cells engineered to express HPV16 oncoproteins E6 and E7, and used it to assess the protective and therapeutic potential of E6/E7-based DNA-immunogens. Methods 4T1luc2 subclon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 676ea262-294e-50f0-a7cf-c322e1efce8d
DOI: 10.21203/rs.3.rs-6328033/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

New mouse model based on adenocarcinoma 4T1 cells expressing HPV16 E6 and E7 applied to assess the efficacy of therapeutic and prophylactic E6/E7-based HPV16 vaccinesDOI 10.21203/rs.3.rs-6328033/v1Read

Design, Immune Responses and Anti-Tumor Potential of an HPV16 E6E7 Multi-Epitope VaccineSemantic proximity Read

NSP4 as Adjuvant for Immunogenicity and Design of Effective Therapeutic HPV16 E6/E7/L1 DNA Vaccine in Tumoric and Healthy C57BL/6 MiceSemantic proximity Read

Customized Viral Immunotherapy for HPV-Associated Cancer.Semantic proximity Read

Characterization of cell lines derived from tumors induced by TC-1 cells in mice preimmunized against HPV16 E7 oncoprotein.Semantic proximity Read

Therapeutic vaccines against HPV16-associated tumors. Minireview.Semantic proximity Read

HPV-positive murine oral squamous cell carcinoma: development and characterization of a new mouse tumor model for immunological studiesSemantic proximity Read

STAT1-Deficient HPV E6/E7-Associated Cancers Maintain Host Immunocompetency against Therapeutic InterventionSemantic proximity Read

Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression ProfilingSemantic proximity Read

Molecular Mechanisms of MmuPV1 E6 and E7 and Implications for Human DiseaseSemantic proximity Read

Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse modelSemantic proximity Read

mRNA-encoded mutant HPV16/18 vaccines promote specific T-cell responses and synergize with anti-PD-1 checkpoint blockade in mediating therapeutic tumor regression in mice.Semantic proximity Read

Optimization of heterologous DNA-prime, protein boost regimens and site of vaccination to enhance therapeutic immunity against human papillomavirus-associated diseaseSemantic proximity Read